Thermo Fisher Scientific MEF2C Monoclonal Antibody (CL0369)
Human MEF2C 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB, IHC, ICC/IF에 사용 가능. Recombinant MEF2C 단백질을 면역원으로 제작되었으며, 고순도 Protein A 정제. 액상 형태로 안정적인 장기 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL0369 |
| Immunogen | Recombinant protein corresponding to Human MEF2C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2786989 |
Product Specific Information
Immunogen sequence:
PPNFEMPVSI PVSSHNSLVY SNPVSSLGNP NLLPLAHPSL QRNSMSPGVT HRPPSAGNTG GLMGGDLTSG AGTSAGNGYG NPRNSPGLLV SPGNLNKNMQ AKSPPPMNLG MNNRKPDLRV LIPPGSKNTM PSVNQRINN
Target Information
MEF2C is a transcription activator that binds specifically to the MEF2 element in regulatory regions of many muscle-specific genes. It controls cardiac morphogenesis and myogenesis and is involved in vascular development. MEF2C plays an essential role in hippocampal-dependent learning and memory by regulating excitatory synapses and synaptic transmission. It is crucial for normal neuronal development, cortical electrical activity, and proper development of megakaryocytes, platelets, and B lymphopoiesis. MEF2C is required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses, and germinal center formation. Isoforms 3 and 4, lacking the repressor domain, are more active than isoforms 1 and 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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