Thermo Fisher Scientific OSMR Monoclonal Antibody (AN-V2), APC, eBioscience
인간 OSM 수용체를 인식하는 AN-V2 단클론 항체로, APC 형광표지되어 Flow Cytometry에 최적화됨. 5 µL/test로 사용하며, JAK/STAT 신호 경로 연구에 적합. 인간 시료 반응성, 4°C 암소 보관.
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Thermo Fisher Scientific OSMR Monoclonal Antibody (AN-V2), APC, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.125 µg)/test
Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AN-V2 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10805393 |
Additional Formats
Product Specific Information
This monoclonal AN-V2 antibody reacts with the human oncostatin M (OSM) receptor. OSM belongs to the interleukin-6 cytokine family and is produced by T cells, activated monocytes, and dendritic cells.
In humans, OSM binds two receptor complexes:
- Type I OSM receptor: composed of LIFR and gp130, recognizes both LIF and OSM.
- Type II OSM receptor: composed of gp130 and OSMR subunit, specifically binds OSM and activates the JAK/STAT signaling pathway.
The antibody also recognizes a soluble form of the OSM receptor, expressed in bone marrow, endothelium, liver, lung, and various tumor cell lines.
The AN-V2 monoclonal antibody specifically recognizes the type II (beta) OSM receptor.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested with A375 cell line at 5 µL (0.125 µg)/test (100 µL final volume).
Cell number range: 10⁵–10⁸ cells/test.
Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Oncostatin M (OSM) is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving hematopoietin receptor superfamily members.
Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds gp130 and, with the leukemia inhibitory factor receptor (LIFR), induces a proliferative response in permissive cells.
OSMR forms an alternative receptor complex (heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF.
Publication Note: This RefSeq record includes a subset of available publications. See Entrez Gene record for additional references.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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