Thermo Fisher Scientific OSMR Monoclonal Antibody (AN-V2), APC, eBioscience

Thermo Fisher Scientific OSMR Monoclonal Antibody (AN-V2), APC, eBioscience™

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µL (0.125 µg)/test
Publications: View 1 publication

Product Specifications

Additional Formats

• PE
• Request custom conjugation

Product Specific Information

This monoclonal AN-V2 antibody reacts with the human oncostatin M (OSM) receptor. OSM belongs to the interleukin-6 cytokine family and is produced by T cells, activated monocytes, and dendritic cells.
In humans, OSM binds two receptor complexes:

• Type I OSM receptor: composed of LIFR and gp130, recognizes both LIF and OSM.
• Type II OSM receptor: composed of gp130 and OSMR subunit, specifically binds OSM and activates the JAK/STAT signaling pathway.

The antibody also recognizes a soluble form of the OSM receptor, expressed in bone marrow, endothelium, liver, lung, and various tumor cell lines.
The AN-V2 monoclonal antibody specifically recognizes the type II (beta) OSM receptor.

Applications Reported: Flow cytometric analysis
Applications Tested: Tested with A375 cell line at 5 µL (0.125 µg)/test (100 µL final volume).
Cell number range: 10⁵–10⁸ cells/test.
Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered.

Target Information

Oncostatin M (OSM) is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving hematopoietin receptor superfamily members.
Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds gp130 and, with the leukemia inhibitory factor receptor (LIFR), induces a proliferative response in permissive cells.
OSMR forms an alternative receptor complex (heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF.

Publication Note: This RefSeq record includes a subset of available publications. See Entrez Gene record for additional references.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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