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Thermo Fisher Scientific Zap-70 Monoclonal Antibody (1E7.2), Alexa Fluor 488
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Thermo Fisher Scientific Zap-70 Monoclonal Antibody (1E7.2), Alexa Fluor 488

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Alexa Fluor 488으로 표지된 Zap-70 단클론 항체로, 인간 및 생쥐 시료에 반응하며 Flow Cytometry에 적합. T세포 수용체 신호전달 연구용으로 사용. 고순도 정제, PBS/BSA 버퍼 및 나트륨 아지드 포함. 4°C 암소 보관.

카탈로그번호
MHZAP7020
판매단위
pk
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마지막 업데이트 2025. 08. 03. 오후 01:41
Thermo Fisher Scientific MHZAP7020 Zap-70 Monoclonal Antibody (1E7.2), Alexa Fluor 488 500 ul pk판매 단위 pk ·
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554,300원VAT 포함 609,730원

Thermo Fisher Scientific · Thermo Fisher Scientific Zap-70 Monoclonal Antibody (1E7.2), Alexa Fluor 488

Thermo Fisher Scientific Zap-70 Monoclonal Antibody (1E7.2), Alexa Fluor 488

Applications


Product Specifications

항목 내용
Species Reactivity Human, Mouse
Published Species Human, Mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Clone 1E7.2
Immunogen GST-fusion protein of Human ZAP70 (amino acids 282–307)
Conjugate Alexa Fluor™ 488
Excitation / Emission Max 499 / 520 nm
Form Liquid
Purification Purified
Storage Buffer PBS with 4 mg/mL BSA
Contains 0.1% Sodium Azide
Storage Conditions 4°C, store in dark
Shipping Conditions Ambient (domestic); Wet ice (international)
RRID AB_10375316

Additional Formats


Product Specific Information

Alexa Fluor™ 488 dye provides an excellent fluorescein (FITC) substitute based on internal testing and customer-reported results.


Target Information

ZAP-70 is a cytosolic protein tyrosine kinase belonging to the Syk family, expressed exclusively in T-cells and natural killer cells. It is essential for T-cell receptor activation. Upon TCR engagement, ZAP70 is phosphorylated on tyrosines 292, 315, and 319 in the interdomain B region.

  • Tyrosine 315: Vav binding site
  • Tyrosine 319: Lck binding site
  • Tyrosine 292: Negatively regulates activation

Phosphorylation of tyrosines 315 and 319 enhances ZAP70-mediated lymphocyte signaling, while phosphorylation at 292 attenuates signaling.


Classification

Analyte Specific Reagent


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