Thermo Fisher Scientific Zap-70 Monoclonal Antibody (1E7.2), Alexa Fluor 488
Alexa Fluor 488으로 표지된 Zap-70 단클론 항체로, 인간 및 생쥐 시료에 반응하며 Flow Cytometry에 적합. T세포 수용체 신호전달 연구용으로 사용. 고순도 정제, PBS/BSA 버퍼 및 나트륨 아지드 포함. 4°C 암소 보관.
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Thermo Fisher Scientific Zap-70 Monoclonal Antibody (1E7.2), Alexa Fluor 488
Applications
- Flow Cytometry (Flow): Assay-Dependent
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E7.2 |
| Immunogen | GST-fusion protein of Human ZAP70 (amino acids 282–307) |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS with 4 mg/mL BSA |
| Contains | 0.1% Sodium Azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10375316 |
Additional Formats
Product Specific Information
Alexa Fluor™ 488 dye provides an excellent fluorescein (FITC) substitute based on internal testing and customer-reported results.
Target Information
ZAP-70 is a cytosolic protein tyrosine kinase belonging to the Syk family, expressed exclusively in T-cells and natural killer cells. It is essential for T-cell receptor activation. Upon TCR engagement, ZAP70 is phosphorylated on tyrosines 292, 315, and 319 in the interdomain B region.
- Tyrosine 315: Vav binding site
- Tyrosine 319: Lck binding site
- Tyrosine 292: Negatively regulates activation
Phosphorylation of tyrosines 315 and 319 enhances ZAP70-mediated lymphocyte signaling, while phosphorylation at 292 attenuates signaling.
Classification
Analyte Specific Reagent
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