Thermo Fisher Scientific ZAP-70 Monoclonal Antibody (1E7.2), PerCP
PerCP 형광 표지된 ZAP-70 단클론 항체로 T세포 및 NK세포 내 ZAP-70 단백질 검출에 사용. Flow Cytometry에 적합하며 488 nm에서 효율적으로 여기됨. 4°C 암소 보관, Wet ice 배송.
- 카탈로그번호
- MHZAP7031
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific ZAP-70 Monoclonal Antibody (1E7.2), PerCP
Applications
- Flow Cytometry (Assay-Dependent)
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E7.2 |
| Immunogen | GST-fusion protein of Human ZAP70, amino acids 282–307 |
| Conjugate | PerCP |
| Excitation / Emission Max | 482 / 675 nm |
| Form | Liquid |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Wet ice |
Additional Formats
Product Specific Information
PerCP conjugates are excited by the 488 nm line of the argon-ion laser and have a large Stokes shift, providing minimal spectral overlap into the R-PE (phycoerythrin) channel.
Target Information
ZAP-70 is a cytosolic protein tyrosine kinase and a member of the Syk family. It is expressed exclusively in T-cells and natural killer (NK) cells and is essential for T-cell receptor activation. Upon TCR engagement, ZAP-70 is phosphorylated on tyrosines 292, 315, and 319 within the interdomain B region. Phosphorylation at tyrosines 315 (Vav binding site) and 319 (Lck binding site) enhances signaling, while phosphorylation at tyrosine 292 attenuates activation.
Regulatory Status
Analyte Specific Reagent
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