Thermo Fisher Scientific HLA-DR Monoclonal Antibody (TU36), PerCP

Applications

• Flow Cytometry (Flow): Assay-dependent
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Product Specifications

Additional Formats

• APC
• FITC
• Pacific Blue
• Pacific Orange
• PE
• PE-Cyanine5.5
• PE-Texas Red
• Qdot 605
• Qdot 655
• Qdot 705
• Request custom conjugation

Product Specific Information

PerCP conjugates are excited by the 488 nm line of the argon-ion laser and have a large Stokes shift, providing minimal spectral overlap into the R-PE (phycoerythrin) channel.
This antibody recognizes the complex of the HLA-DR chains but not the individual chains.

Target Information

HLA-DR, a member of the MHC class II family, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB).

• The DRA gene contains 5 exons: exon 1 encodes the leader peptide, exons 2–3 encode extracellular domains, and exon 4 encodes the transmembrane and cytoplasmic regions.
• The DRA chain lacks polymorphisms in the peptide-binding region and pairs with DRB1, DRB3, DRB4, and DRB5 beta chains.
• The DRB chain contains polymorphisms determining peptide-binding specificity.
• HLA-DR is expressed on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.

Three loci—DR, DQ, and DP—encode major human class II molecules that bind processed peptides, present them to T-helper cells, and initiate immune responses.
HLA and MHC antibodies are valuable tools in Immunopeptidomics, aiding in the identification and characterization of neoantigens via LC-MS/MS.

Analyte Specific Reagent

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