Thermo Fisher Scientific SARS-CoV-2 Spike Protein (RBD) Chimeric Recombinant Rabbit Monoclonal Antibody (Sb#45)
SARS-CoV-2 스파이크 단백질 RBD를 인식하는 키메라형 재조합 토끼 단클론 항체입니다. ELISA 및 기능적 억제 분석에 적합하며, HEK293 세포에서 발현되었습니다. Protein A로 정제된 액상 형태로 제공되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| ELISA | Assay-dependent |
| Functional Assay | Assay-dependent |
| Inhibition Assays | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Rabbit / IgG, Fc |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Sb#45 |
| Immunogen | This clone was originally isolated in a form of a synthetic nanobody (sybody) via a target swap selection procedure against RBD-vYFP using ribosomal display and against RBD-Fc fusion during phage display rounds. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody recognizes and binds the SARS-CoV-2 C-terminal receptor binding domain (RBD) located in the extracellular portion of the spike protein.
Target Information
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), also known as 2019-nCoV, causes illnesses ranging from mild cold symptoms to severe respiratory distress and death.
The Spike (S) protein is critical for viral attachment, fusion, and entry, and serves as a key target for antibody development, entry inhibitors, and vaccines.
The receptor-binding domain (RBD, S-RBD) of the SARS-CoV-2 Spike protein binds strongly to human and bat ACE2 receptors, exhibiting higher binding affinity than the SARS-CoV RBD.
The S1 subunit contains the RBD responsible for specific binding to the ACE2 receptor on target cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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