Thermo Fisher Scientific Phl p 1 Chimeric Recombinant Human Monoclonal Antibody (Clone 25)
Phl p 1 알레르겐을 인식하는 인간 단클론 항체로, Western blot, ELISA, Dot blot에 사용 가능. 다양한 잔디 알레르겐과 교차 반응성을 보이며, 알레르기 연구에 활용 가능. HEK293 세포에서 발현된 IgE 아이소타입 재조합 항체.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| ELISA | 10 µg/mL | - |
| Dot blot (DB) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Plant |
| Host / Isotype | Human / IgE, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Clone 25 |
| Immunogen | Recombinant Phl p 1, a grass pollen allergen |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody binds to the Timothy grass allergen Phl p 1 and shows cross-reactivity with natural group 1 allergens from a variety of grass species such as oat, sweet vernal grass, Bermuda grass, rye grass, common reed, Kentucky blue grass, rye, wheat, and maize (weak).
Target Information
Phl p 1 binds to specific receptors on the surface of immune cells, including TLR4 (Toll-like receptor 4) and MD-2 (myeloid differentiation factor 2).
This interaction triggers a signaling cascade that activates immune cells and releases inflammatory mediators, leading to allergic symptoms.
The Phl p 1–TLR4–MD-2 interaction is a key mechanism in grass pollen allergy development and provides insights for potential therapeutic strategies against allergic reactions.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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