Thermo Fisher Scientific ASH2L Recombinant Rabbit Monoclonal Antibody (ARC0326)
ASH2L 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단일클론 항체. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용 가능. HEK293 발현 시스템 기반, 고순도 친화 크로마토그래피 정제. 인체, 마우스, 랫트 반응성.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0326 |
| Immunogen | Synthetic peptide within amino acids 529–628 of human ASH2L (Q9UBL3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.25 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849501 |
Product Specific Information
Immunogen Sequence:
AEKSLKQTPH SEIIFYKNGV NQGVAYKDIF EGVYFPAISL YKSCTVSINF GPCFKYPPKD LTYRPMSDMG WGAVVEHTLA DVLYHVETEV DGRRSPPWEP
Target Information
The human ASH2L gene encodes a 628 amino acid protein (ASH2L1, isoform 1) containing a nuclear localization signal and a PHD finger motif, suggesting a role as a transcription regulator. Its predicted molecular weight is 68.7 kDa, with isoforms at 60 kDa and 56.5 kDa due to alternative splicing.
Human ASH2L shares 60% homology with Drosophila ash2, which regulates gene expression during early development, and 90% homology with mouse ASH2L. Expression is predominant in adult heart, testis, and fetal lung and liver, with low levels in adult lung, liver, kidney, prostate, and peripheral leukocytes. It is also expressed in leukemia cell lines (K562, Hel, Dami) associated with erythroid and megakaryocytic potential. Differentiation inducers such as phorbol ester and hemin alter expression patterns, suggesting ASH2L’s role in hematopoiesis and leukemia. ASH2L may interact with beta-tubulin and beta-catenin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: MA5-35601_ASH2L_Q9UBL3-1_Rabbit.svg, MA5-35601_ASH2L_Q9UBL3-1_Rabbit_PDP.jpeg)
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