Thermo Fisher Scientific PIP5K1A Polyclonal Antibody
Thermo Fisher Scientific의 PIP5K1A Polyclonal Antibody는 인간 및 마우스 시료에 반응하며, Western blot, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 항체로, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
- 카탈로그번호
- PA529405
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 1–180 of Human PIP5K1A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.41 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546881 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji
- Predicted reactivity: Mouse (94%), Rat (93%), Xenopus laevis (81%), Dog (95%), Pig (96%), Chicken (87%), Rhesus Monkey (97%), Chimpanzee (98%), Bovine (94%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase 1 alpha)는 phosphatidylinositol-4-phosphate를 인산화하여 phosphatidylinositol 4,5-bisphosphate를 생성하는 lipid kinase입니다.
PIP5K1은 Wnt3a에 의해 유도된 LRP6의 ser1490 인산화에 필요하며, Wnt3a는 frizzled 및 disheveled 경로를 통해 PIP5KI를 활성화시킵니다.
또한, PIP5K1A 매개 PIP(2) 생성은 HIV-1의 세포 진입 및 초기 감염 단계에 필수적이며, PI4P5K1A 과발현은 HIV-1 Env 매개 PIP(2) 생성과 바이러스 복제를 증가시킵니다.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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