Thermo Fisher Scientific EphB1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100

Product Specifications

Target Information

EPHB1 is a receptor tyrosine kinase belonging to the ephrin receptor family. Members of the Eph family play key roles in biological processes such as nervous system development, angiogenesis, and synapse formation and maturation. EphB1 and other EphB family members are type I membrane proteins composed of immunoglobulin, fibronectin type III, and cysteine-rich subdomains in the ectodomain, with a cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain. EphB family proteins bind ephrins of the B class, which are transmembrane ligands capable of bidirectional signaling. EphB1 is predominantly expressed in developing neural structures and vascular epithelium of the kidney and other tissues. Upon binding to oligomerized ephrin B1, EphB1 regulates cell attachment and assembly. Members of this family are implicated in neuronal and vascular cell targeting.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.