Thermo Fisher Scientific PCSK2 Polyclonal Antibody
PCSK2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, Flow cytometry에 사용 가능. Human 및 Mouse 반응성 검증됨. KLH 결합 합성 펩타이드로 면역화. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 | – |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | – |
| Flow Cytometry (Flow) | 1:10–1:50 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 87–116 amino acids from the N-terminal region of human PCSK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2299126 |
Product Specific Information
This antibody is predicted to react with porcine and rat based on sequence homology.
Target Information
The subtilisin-like prohormone convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins transported by the constitutive secretory pathway are also targeted for maturation by PCs.
PC family members share structural similarities, including:
- A heterogeneous ~10 kDa amino-terminal proregion
- A highly conserved ~55 kDa subtilisin-like catalytic domain
- A carboxyl-terminal domain heterogeneous in length and sequence
These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region and the trans-Golgi network, whereas PC2 is found in the trans-Golgi network and diffusely distributed in the peripheral cytoplasm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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