Thermo Fisher Scientific VKORC1 Polyclonal Antibody
VKORC1 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간 및 생쥐 시료에 반응합니다. Western blot과 IHC 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 2–8°C에서 보관 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid synthetic peptide near the amino terminus of human VKORC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551710 |
Product Specific Information
- Suggested positive control: A549 cell lysate
- PA5-34358 can be used with blocking peptide PEP-1401.
Target Information
Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the enzyme responsible for reducing vitamin K 2,3-epoxide to its active form, which is essential for blood clotting.
The reduced form of vitamin K is required for the carboxylation of glutamic acid residues in certain blood-clotting proteins.
Vitamin K deficiency or inhibition by warfarin can lead to fatal bleeding. VKORC1 is sensitive to warfarin, and mutations in this gene are associated with deficiencies in vitamin-K-dependent clotting factors and warfarin resistance in humans and rats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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