Thermo Fisher Scientific LXR beta Monoclonal Antibody (K8917)
인간 LXR beta에 특이적인 Mouse IgG2a 단클론 항체로, Western blot, ELISA, IP에 사용 가능. 인간 LXR alpha 및 rat LXR beta와 교차 반응 없음. 액상 형태, 1 mg/mL 농도, 냉장 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| ELISA | 0.1 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K8917 |
| Immunogen | Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human LXR-beta (2-86 aa). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | Physiological saline |
| Contains | 0.1% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 1 month. For long-term storage store at -20°C. |
| Shipping conditions | Wet ice |
| RRID | AB_2532201 |
Product Specific Information
This antibody specifically recognizes human LXR beta but does not recognize human LXR alpha.
This antibody does not cross-react with rat LXR beta.
Not yet tested in other species.
Target Information
The liver X receptors (LXRA and LXRB) form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation.
LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed.
Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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