Thermo Fisher Scientific LXR alpha Monoclonal Antibody (K8607)
LXR alpha 단백질을 특이적으로 인식하는 Mouse IgG2a 단클론 항체로, Human 시료에 반응합니다. Western blot, ELISA, IP, ChIP, Gel Shift 등 다양한 실험에 사용 가능하며, 액상 형태로 제공됩니다. 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Thermo Fisher Scientific LXR alpha Monoclonal Antibody (K8607)
Applications 및 Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | - |
| ELISA (ELISA) | 0.3 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
| ChIP assay (ChIP) | Assay-dependent | - |
| Gel Shift (GS) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K8607 |
| Immunogen | Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human LXR-alpha (2–97 aa). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | Physiological saline |
| Contains | 0.1% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 1 month. For long-term storage, store at -20°C. |
| Shipping conditions | Wet ice |
| RRID | AB_2532199 |
Product Specific Information
This antibody specifically recognizes LXR alpha but does not recognize human LXR beta.
Target Information
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES.
LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides.
NR1H3 plays an important role in cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also functionally interplays with RORA for the regulation of genes involved in liver metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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