Thermo Fisher Scientific GPR37 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 20 µg/mL

Product Specifications

Product Specific Information

• Percent identity with other species by BLAST analysis:
  Human, Gorilla (100%); Monkey, Rabbit (88%); Gibbon, Bovine (81%).
• For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
  After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

Parkinson’s disease is the second most common neurodegenerative disorder after Alzheimer’s disease, affecting about 1% of people over 65 and 3% over 75. Mutations in the Park2 gene are a major cause of Parkinson’s disease. Park2 may play a role in the ubiquitin-mediated proteolytic pathway, and its mutations are associated with autosomal recessive juvenile parkinsonism. Panneuronal expression of Parkin substrate Pael-R causes age-dependent degeneration of dopaminergic neurons; coexpression of Parkin degrades Pael-R and suppresses its toxicity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.