Thermo Fisher Scientific GPR37 Polyclonal Antibody
Rabbit polyclonal antibody against human GPR37 protein. Validated for IHC (Paraffin) at 20 µg/mL. Recognizes N-terminal extracellular domain of GPR37. Suitable for neurodegenerative disease research including Parkinson’s studies. For research use only.
- 카탈로그번호
- PA532826
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from N-terminal extracellular domain of human GPR37 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550288 |
Product Specific Information
- Percent identity with other species by BLAST analysis:
Human, Gorilla (100%); Monkey, Rabbit (88%); Gibbon, Bovine (81%). - For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
Parkinson’s disease is the second most common neurodegenerative disorder after Alzheimer’s disease, affecting about 1% of people over 65 and 3% over 75. Mutations in the Park2 gene are a major cause of Parkinson’s disease. Park2 may play a role in the ubiquitin-mediated proteolytic pathway, and its mutations are associated with autosomal recessive juvenile parkinsonism. Panneuronal expression of Parkin substrate Pael-R causes age-dependent degeneration of dopaminergic neurons; coexpression of Parkin degrades Pael-R and suppresses its toxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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