Thermo Fisher Scientific TAB182 Polyclonal Antibody
TAB182 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용에 최적화. 인간 시료 반응성, 고순도 친화성 크로마토그래피 정제, -20°C 보관 안정성.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TNKS1BP1 (Accession Q9C0C2), corresponding to amino acid residues H1605–A1655 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818657 |
Product Specific Information
Antibody detects endogenous levels of total TAB182.
Target Information
TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen searching for tankyrase 1-interacting proteins.
Tankyrase 1 is a poly(ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor).
Ribosylation of TRF1 inhibits TRF1 binding and induces telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain, suggesting TAB182 may act as a scaffold to mediate higher-order protein complex formation at telomeres.
TAB182 has also been found to localize to the cytoplasmic cortical actin network, suggesting a potential cytoplasmic role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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