Thermo Fisher Scientific HSP701L Polyclonal Antibody
Thermo Fisher Scientific의 HSP701L 폴리클로날 항체는 인간, 마우스, 랫트에 반응하며 Western blot 및 ICC/IF에 적합합니다. 고순도 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 1 mg/mL 농도로 제공됩니다. 연구용으로만 사용됩니다.
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- PA528202
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Thermo Fisher Scientific HSP701L Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:10,000
- Immunocytochemistry (ICC/IF): 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 335–639 of Human HSP70 1L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2545678 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji, mouse testis, rat testis, U87-MG, SK-N-SH, IMR32, SK-N-AS
- Predicted reactivity: Mouse (93%), Rat (92%), Xenopus laevis (81%), Pig (94%), Bovine (94%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Cells respond to environmental stress by increasing expression of heat shock proteins. The small heat shock proteins (15–30 kDa) are diverse and found across species. Elevated expression of these proteins has been linked to neoplasia, including estrogen-induced proteins in breast cancer cells. Hsp27 shows rapid phosphorylation in response to mitogens and tumor promoters. Expression of a 24 kDa estrogen-induced protein correlates with steroid hormone receptor levels and is highly expressed in breast carcinoma. Studies also associate Hsp27 levels with endometrial adenocarcinomas. Regulation of Hsp27 by estrogens and heat shock parallels ecdysteroid and heat shock activation in Drosophila Hsp20 genes.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-28202_HSP701L_P34931-1_Rabbit_PDP.jpeg, PA5-28202_HSP701L_P34931-1_Rabbit.svg)
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