Thermo Fisher Scientific NEDD4 Polyclonal Antibody
NEDD4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 종(Human, Mouse, Rat 등)에 반응하며 Western blot에 적합. 항원 친화 크로마토그래피로 정제된 고순도 항체로 연구용에 적합.
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Thermo Fisher Scientific NEDD4 Polyclonal Antibody
Applications
- Western Blot (WB): Tested Dilution 4–6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Horse, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (950 DKLQMAIENTQGFDGVD 1000) of NEDD4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540992 |
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in degradation of VEGFR-2/KDFR independently of ubiquitin-ligase activity, and acts as a potential proto-oncogene negatively regulating PTEN via ubiquitination. NEDD4 also participates in viral budding and regulation of epithelial Na⁺ channels affecting arterial hypertension. It is localized to the sarcolemmal region of muscle fibers, and increased expression correlates with muscle unloading, denervation, and reduced Notch1 expression, functioning as a down regulator of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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