Thermo Fisher Scientific TLR7 Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 Rabbit Polyclonal TLR7 항체로, IHC(P/F) 및 Flow Cytometry에 사용 가능. KLH 결합 합성 펩타이드(aa 684-701)를 면역원으로 제작. 단백질 G 정제, PBS 버퍼 및 0.05% sodium azide 함유. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:20 |
| Flow Cytometry (Flow) | 0.5–2 µg per million cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 684–701 of human TLR7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540988 |
Product Specific Information
Suggested positive control: antigen standard for TLR7 (transient overexpression lysate), Ramos.
Target Information
TLR7 is a highly conserved membrane protein of the Toll-like receptor (TLR) family with 27 leucine-rich repeats (LRR) and a TIR domain. It plays a key role in pathogen recognition and activation of innate immunity. TLR7 is activated by single-stranded RNA viruses such as influenza and vesicular stomatitis virus (VSV). It is predominantly expressed in lung, placenta, and spleen, and is located near TLR8. TLR7 signals via MyD88 and TRAF6, leading to NF-κB activation, cytokine secretion, and inflammatory responses. It recognizes pathogen-associated molecular patterns (PAMPs) and mediates cytokine production essential for effective immune defense.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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