Thermo Fisher Scientific CDK2AP1 Polyclonal Antibody
CDK2AP1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. 인간 CDK2AP1의 1-115 아미노산 서열을 면역원으로 사용했습니다. 세포주 U-87MG, 22Rv1, 293T, HeLa에서 양성 반응 확인되었습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5120885
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500 - 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–115 of human CDK2AP1 (NP_004633.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.17 mg/mL |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2914457 |
Product Specific Information
Positive test controls include: U-87MG, 22Rv1, 293T, HeLa.
Target Information
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2)-associated protein that negatively regulates CDK2 activity by sequestering monomeric CDK2 and targeting it for proteolysis.
It also interacts with DNA polymerase alpha/primase and mediates phosphorylation of the large p180 subunit, suggesting a regulatory role in DNA replication during the S-phase of the cell cycle.
Additionally, this protein forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex, which epigenetically regulates embryonic stem cell differentiation.
Thus, this gene plays roles in both cell-cycle and epigenetic regulation.
Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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