Thermo Fisher Scientific CDK2AP1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500 - 1:2,000

Product Specifications

Product Specific Information

Positive test controls include: U-87MG, 22Rv1, 293T, HeLa.

Target Information

The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2)-associated protein that negatively regulates CDK2 activity by sequestering monomeric CDK2 and targeting it for proteolysis.
It also interacts with DNA polymerase alpha/primase and mediates phosphorylation of the large p180 subunit, suggesting a regulatory role in DNA replication during the S-phase of the cell cycle.
Additionally, this protein forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex, which epigenetically regulates embryonic stem cell differentiation.
Thus, this gene plays roles in both cell-cycle and epigenetic regulation.
Alternative splicing results in multiple transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.