Thermo Fisher Scientific LONP1 Polyclonal Antibody
LONP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, ELISA, IP 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 고순도 Affinity Chromatography 정제 및 안정적 PBS/glycerol 저장.
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Thermo Fisher Scientific LONP1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5 µg–4 µg antibody for 200 µg–400 µg extracts |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 120–400 of human LONP1 (NP_004784.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.43 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914459 |
Product Specific Information
Positive test controls include: A-549, HL-60, LO2, HT-1080, BT-474, Mouse heart, Mouse kidney, Mouse liver, Rat kidney.
The target is usually found in the following locations: Mitochondrion matrix.
Immunogen sequence:
VFPHLPLIAI TRNPVFPRFI KIIEVKNKKL VELLRRKVRL AQPYVGVFLK RDDSNESDVV ESLDEIYHTG TFAQIHEMQD LGDKLRMIVM GHRRVHISRQ LEVEPEEPEA ENKHKPRRKS KRGKKEAEDE LSARHPAELA MEPTPELPAE VLMVEVENVV HEDFQVTEEV KALTAEIVKT IRDIIALNPL YRESVLQMMQ AGQRVVDNPI YLSDMGAALT GAESHELQDV LEETNIPKRL YKALSLLKKE FELSKLQQRL GREVEEKIKQ THRKYLLQEQ L
Target Information
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases.
This protein mediates the selective degradation of misfolded, unassembled, or oxidatively damaged polypeptides in the mitochondrial matrix.
It may also have a chaperone function in the assembly of inner membrane protein complexes and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome.
Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia.
Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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