Thermo Fisher Scientific EGF Monoclonal Antibody (OTI8E2), TrueMAB
EGF 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot에 최적화되어 있습니다. Human 시료에 반응하며, 동결건조 형태로 제공됩니다. PBS buffer(8% trehalose)로 안정화되어 있으며, 재구성 후 1 mg/mL 농도로 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8E2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1054–1207 of human EGF produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Epidermal Growth Factor (EGF) binds to the EGF Receptor (EGFR), a 170 kDa protein kinase, initiating multiple signaling pathways involved in cell growth and survival. EGFR forms homo- or heterodimers with other family members, each triggering distinct downstream cascades such as RAS-RAF-MEK-ERK, PI3K-AKT, PLCγ-PKC, and STAT. EGF is widely expressed in the kidney, cerebrum, prostate, and salivary glands, functioning as a potent mitogenic factor. Dysregulation of EGF signaling is associated with various cancers and genetic disorders such as hypomagnesemia type 4.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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