Thermo Fisher Scientific TBLR1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human TBLR1. Validated for Western blot with 1–3 µg/mL dilution. Cross-reacts with mouse and rat. Supplied as liquid at 0.5 mg/mL concentration. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
- Suggested Positive Control: Human brain tissue or human brain protein
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 200–250 of human TBLR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2199909 |
Product Specific Information
- This antibody may cross-react with mouse and rat TBLR1, based on sequence homology.
- Suggested positive control: human brain tissue, human brain protein.
Target Information
Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells.
The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT) participate in transcriptional repression pathways.
N-CoR and SMRT form large protein complexes that recruit histone deacetylases (HDACs) to generate repressive chromatin.
HDAC3 is the main HDAC associated with these complexes and is essential for repression.
TBLR1 is a WD-40 repeat protein that associates with both N-CoR and SMRT complexes, though its precise role remains to be elucidated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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