Thermo Fisher Scientific RAP1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Suggested positive control: 293 whole cell lysate, antigen standard for TERF2IP (transient overexpression lysate).

Target Information

Human Rap1 was the first identified ortholog of the yeast telomeric protein scRap1, which shares three conserved sequence motifs in common. HRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1.
The hRap1 cDNA codes for a protein of 399 amino acids with an approximate molecular weight of 47 kDa. The hRap1 protein does not interact with TRF1. TRF2 is a ubiquitously expressed protein implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif, binds to duplex TTAGGG repeats, and localizes to all human telomeres in metaphase chromosomes.
TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. Mutant forms of TRF2 are implicated in the prevention of senescence in primary human cells. Inhibition of TRF2 has been shown to result in apoptosis in a subset of mammalian cell types.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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