Thermo Fisher Scientific RAP1 Polyclonal Antibody
RAP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ICC/IF, IP에 사용 가능. Human, Mouse, Gerbil 반응성. 단백질 G 정제, 1.0 mg/mL 농도, PBS에 0.02% sodium azide 포함. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | |
| Immunocytochemistry (ICC/IF) | 2–10 µg/mL | |
| Immunoprecipitation (IP) | Assay-Dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Gerbil, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 212–235 of human Rap1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1087032 |
Product Specific Information
Suggested positive control: 293 whole cell lysate, antigen standard for TERF2IP (transient overexpression lysate).
Target Information
Human Rap1 was the first identified ortholog of the yeast telomeric protein scRap1, which shares three conserved sequence motifs in common. HRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1.
The hRap1 cDNA codes for a protein of 399 amino acids with an approximate molecular weight of 47 kDa. The hRap1 protein does not interact with TRF1. TRF2 is a ubiquitously expressed protein implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif, binds to duplex TTAGGG repeats, and localizes to all human telomeres in metaphase chromosomes.
TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. Mutant forms of TRF2 are implicated in the prevention of senescence in primary human cells. Inhibition of TRF2 has been shown to result in apoptosis in a subset of mammalian cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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