Thermo Fisher Scientific Caspase 5 Polyclonal Antibody
Caspase 5 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, 인체·생쥐·랫드 반응성을 보입니다. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능하며, Protein A로 정제된 1 mg/mL 농도의 액상 제품입니다. 연구용 전용 시약입니다.
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Thermo Fisher Scientific Caspase 5 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Caspase 5, amino acids 261–360 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Caspases are a family of cysteine proteases divided into apoptotic and inflammatory subfamilies. Unlike apoptotic caspases, inflammatory caspases are associated with immune responses to microbial pathogens. Members include caspase-1, -4, -5, and -12. Activation of these caspases leads to cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18. Caspase-5 interacts with caspase-1 as part of the NALP1 inflammasome, which triggers cleavage of pro-IL-1β. Its expression can be regulated by LPS and IFN-γ.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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