Thermo Fisher Scientific ITPKB Polyclonal Antibody
ITPKB 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. Western blot 및 Immunocytochemistry에 적합하며, 고순도 Affinity chromatography로 정제된 액상 항체입니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ITPKB (Accession P27987), corresponding to amino acid residues P175–L225 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850543 |
Product Specific Information
Antibody detects endogenous levels of total IP3KB.
Target Information
Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) regulates intracellular calcium levels by releasing calcium from intracellular stores. Ins(1,4,5)P3 is phosphorylated by inositol 1,4,5-trisphosphate 3-kinase (IP3K) to form inositol 1,3,4,5-tetrakisphosphate (Ins(1,4,5)P4), which is thought to regulate calcium influx across the plasma membrane.
IP3K exists as three isoforms: IP3KA, IP3KB, and IP3KC. IP3KA is mainly expressed in rat brain and testis, while IP3KB is expressed in various rat tissues such as lung, thymus, testis, brain, and heart.
IP3K activity is stimulated by calmodulin through phosphorylation by cAMP-dependent protein kinase, protein kinase C, or calcium/calmodulin-dependent protein kinase II, mediating inositol phosphate signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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