Thermo Fisher Scientific bFGF Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

FGF2 (also known as FGFb, fibroblast growth factor basic) is a member of the fibroblast growth factor family. It binds to high-affinity transmembrane receptors to regulate cell proliferation and tissue neovascularization.
FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is cytosolic and acts through cell surface receptors, while the 22, 22.5, 24, and 34 kDa isoforms are nuclear and may signal independently of receptor pathways.

In humans, the FGF2 gene is located on chromosome 4q. It is involved in diverse biological processes such as limb and nervous system development, wound healing, and tumor growth.
The mRNA contains multiple polyadenylation sites and can be translated from non-AUG and AUG initiation codons, producing isoforms with distinct properties.
CUG-initiated isoforms localize in the nucleus and mediate intracrine effects, while AUG-initiated forms are cytosolic, mediating paracrine and autocrine effects.
FGF2 dysfunction has been linked to diseases such as Kaposi Sarcoma and corneal neovascularization.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.