Thermo Fisher Scientific NaV1.7 (SCN9A) Polyclonal Antibody, Atto 633

Thermo Fisher Scientific NaV1.7 (SCN9A) Polyclonal Antibody, Atto 633

Applications

• Immunohistochemistry (IHC)

Tested Dilution: Assay-dependent
Publications: [References available upon request]

Product Specifications

Product Specific Information

• Reconstitution: Add 50 µL double distilled water (DDW), depending on sample size.
• Ships as lyophilized powder at room temperature; store at -20°C upon arrival.
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For long-term storage, aliquot and keep at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge antibody preparations before use (10,000 × g, 5 min).

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels possess two short intracellular amino and carboxyl termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
ENaC isoforms (alpha, beta, gamma) are expressed in kidney, lung, and colon, playing a crucial role in sodium and fluid balance. ENaC mediates aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure.
Gain-of-function mutations in beta or gamma ENaC may cause Liddell’s syndrome (hypertension), while loss-of-function mutations in alpha or beta ENaC can lead to pseudohypoaldosteronism (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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