Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (SPM590)

Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (SPM590)

Applications and Tested Dilutions

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or pyrimidine nucleotide starvation. Upon activation, p53 induces transcription of genes such as p21waf1, leading to G1 or G2/M arrest. Structurally, p53 consists of an N-terminal transactivation domain, a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain.

Phosphorylation at Ser15 is critical for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays a vital role in preventing proliferation of damaged cells and functions as an anticancer agent. It is also linked to aging, oxidative stress, and cognitive processes such as long-term potentiation (LTP). Normal cells express p53 at low levels, but transformed cell lines show high expression contributing to malignancy. Mutations in the TP53 gene can lead to loss of tumor suppressor activity and are found in many human cancers, including hereditary cancer syndromes like Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.