Thermo Fisher Scientific P-Glycoprotein Monoclonal Antibody (F4)
P-Glycoprotein을 표적하는 F4 클론 단일클론 항체로, Hamster 및 Human 시료에 반응합니다. Western blot, Flow cytometry, Immunocytochemistry에 적합하며, 단백질 G로 정제된 액상 형태입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:10–1:200 | View 12 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:10–1:100 | View 13 publications |
| Flow Cytometry (Flow) | 2 µg/test | View 2 publications |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Hamster, Human |
| Published Species | Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F4 |
| Immunogen | Human and hamster drug-resistant viable cells followed by crude plasma membranes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979045 |
Product Specific Information
MA5-13854 targets p170 in FACS, WB, and ICC/IF applications and shows reactivity with Hamster and Human samples.
This antibody does not react with mouse tissue in Western blot applications.
The MA5-13854 immunogen is human and hamster drug-resistant viable cells followed by crude plasma membranes.
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.
ABC proteins transport various molecules across extra- and intra-cellular membranes.
ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MDR/TAP subfamily, which is involved in multidrug resistance.
It acts as an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity, contributing to decreased drug accumulation in multidrug-resistant cells and mediating resistance to anticancer drugs.
Additionally, this protein functions as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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