Thermo Fisher Scientific P-Glycoprotein Monoclonal Antibody (F4)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:10-1:200

View 12 publications 12 publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

-

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:10-1:100

View 13 publications 13 publications

Flow Cytometry (Flow)

2 µg/test

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Hamster, Human

Published species

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

F4

Immunogen

Human and hamster drug-resistant viable cells followed by crude plasma membranes if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:P-Glycoprotein (ABCB1),uniProtId:P08183-1,ncbiNodeId:9606,antigenRange:1-1280,antigenLength:1280,antigenImageFileName:MA5-13854_P-Glycoprotein_ABCB1_P08183-1_House_mouse.svg,antigenImageFileNamePDP:MA5-13854_P-Glycoprotein_ABCB1_P08183-1_House_mouse_PDP.jpeg,sortOrder:1},{targetFamily:P-Glycoprotein (ABCB1),uniProtId:P21448-1,ncbiNodeId:10026,antigenRange:1-1276,antigenLength:1276,antigenImageFileName:MA5-13854_P-Glycoprotein_ABCB1_P21448-1_House_mouse.svg,antigenImageFileNamePDP:MA5-13854_P-Glycoprotein_ABCB1_P21448-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10979045

Product Specific Information

MA5-13854 targets p170 in FACS, WB and ICC/IF applications and shows reactivity with Hamster and Human samples. This antibody does not react with mouse tissue in Western blot applications.

The MA5-13854 immunogen is human and hamster drug-resistant viable cells followed by crude plasma membranes.

Target Information

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.