Thermo Fisher Scientific MLL1 Recombinant Rabbit Monoclonal Antibody (BL-175-7E8)
Recombinant rabbit monoclonal antibody recognizing human MLL1 (KMT2A). Validated for Western blot and immunoprecipitation. Produced in HEK293 cells, purified by ion-exchange chromatography. Supplied as liquid, 1 mg/mL, stored at 4°C. For research use o...
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Applications and Tested Dilutions
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunoprecipitation (IP) | 10 µL / 0.5 mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BL-175-7E8 |
| Immunogen | Synthetic peptide representing a region between residues 720 and 780 of human myeloid/lymphoid or mixed-lineage leukemia 1 (KMT2A). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | BBS, pH 8.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
KMT2A (MLL1) is a histone methyltransferase essential for early development and hematopoiesis. It functions as the catalytic subunit of the MLL1/MLL complex, which mediates methylation of Lys-4 of histone H3 (H3K4me) and acetylation of Lys-16 of histone H4 (H4K16ac). Within the complex, KMT2A specifically mediates H3K4 methylation, a key mark of epigenetic transcriptional activation. The enzyme exhibits weak methyltransferase activity alone and requires other MLL1 complex components for full activity. It shows no activity toward histone H3 phosphorylated on Thr-3, reduced activity toward H3 dimethylated on Arg-8 or Lys-9, and higher activity toward H3 acetylated on Lys-9. KMT2A is required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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