Thermo Fisher Scientific GRP94/HSP90B1 (Endoplasmic Reticulum Marker) Monoclonal Antibody (9G10.F8.2)
GRP94/HSP90B1 단백질을 표적하는 Thermo Fisher Scientific의 단클론 항체로, ER 마커로 사용됩니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합하며, Rat IgG2a 형식으로 제작되었습니다. 단백질 A/G 정제, PBS buffer, 보존제 없음.
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Thermo Fisher Scientific GRP94/HSP90B1 (Endoplasmic Reticulum Marker) Monoclonal Antibody (9G10.F8.2)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Bovine, Dog, Chicken, Horse, Guinea pig, Hamster, Human, Mouse, Non-human primate, Sheep, Pig, Rabbit, Rat, Xenopus |
| Host / Isotype | Rat / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9G10.F8.2 |
| Immunogen | Purified glucose regulated protein 94 (GRP94) from chicken oviducts |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
GRP94 is an 803 amino acid protein belonging to the heat shock protein 90 family. It functions as a molecular chaperone involved in the processing and transport of secreted proteins. GRP94 and its N-terminal fragment stimulate CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC). It plays a key role in innate and adaptive immunity, dendritic cell maturation and chemotaxis, antibody production, and cross-priming. GRP94 serves as a potential marker in breast cancer and assists peptide loading of MHC class I molecules. Expression of GRP94 suppresses A23187-induced apoptosis and stabilizes calcium homeostasis. It is expressed in melanoma, liver metastases of colon carcinoma, and human gastric carcinoma BGC-823 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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