Thermo Fisher Scientific MAVS Recombinant Rabbit Monoclonal Antibody (20H41L5)
인간 MAVS 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot에 적합합니다. Expi293 시스템에서 발현되며 Protein A로 정제되었습니다. PBS 완충액에 보관되며 0.09% sodium azide를 포함합니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 20H41L5 |
| Immunogen | Protein corresponding to human MAVS (aa250–aa540) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809228 |
Product Specific Information
This antibody is predicted to react with Monkey, Mouse, Rat, and Bovine.
Target Information
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway relies on Toll-like receptor (TLR) family members, while the other uses RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA.
MAVS is a mitochondrial membrane protein that plays a critical role in IFN-beta signaling pathways by recruiting IRF-3 to RIG-I, leading to activation of NF-kappa-B.
MAVS interacts with TLR adapter protein TRIF, TRAF2, and TRAF6, as well as IKK-alpha, IKK-beta, and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to evade the host immune system. Multiple isoforms of MAVS are known to exist.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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