Thermo Fisher Scientific Phospho-Tau protein (Ser416) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Tau is a neuronal microtubule-associated protein predominantly found on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus interacts with neural plasma membrane components, functioning as a linker between them. Axonal polarity is determined by TAU/MAPT localization within the neuronal cell body domain defined by the centrosome.

Short isoforms of Tau contribute to cytoskeletal plasticity, whereas longer isoforms support stabilization. In its hyperphosphorylated form, Tau is the major component of paired helical filaments (PHFs), which form neurofibrillary tangles characteristic of Alzheimer’s disease (AD). Hyperphosphorylation disrupts Tau’s microtubule-binding function, leading to microtubule destabilization and neuronal degeneration in AD.

Tau phosphorylation is mediated by several serine/threonine kinases, including GSK-3β, PKA, cdk5, and casein kinase II. Hyperphosphorylated Tau is also associated with other neurodegenerative disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.