Thermo Fisher Scientific TRPV4 Polyclonal Antibody
TRPV4 단백질을 인식하는 Sheep polyclonal antibody로, WB와 IHC에 사용 가능. 비결합형(Unconjugated) 형태의 동결건조 제품이며, 4°C 또는 -20°C에서 보관. 삼투압 및 기계적 자극 감지 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from 1t cytoplasmic domain of rat TRPV4 conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2209407 |
Product Specific Information
Reconstitute with 100 µL of distilled water.
Target Information
TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a cation-selective channel activated in response to systemic osmotic pressure. It functions as a non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity.
TRPV4 belongs to the OSM9-like transient receptor potential channel (OTRPC) subfamily within the TRP superfamily.
Mutations in the TRPV4 gene are associated with spondylometaphyseal and metatropic dysplasia, and hereditary motor and sensory neuropathy type IIC.
Diseases linked to TRPV4 include Metatropic Dysplasia and Spondylometaphyseal Dysplasia, Kozlowski Type.
Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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