Thermo Fisher Scientific RNaseL Monoclonal Antibody (2E9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000

-

ELISA (ELISA)

1:100-1:2,000

-

Product Specifications

Species Reactivity

Hamster, Human, Non-human primate

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2E9

Immunogen

Purified, full-length, recombinant, human RNaseL produced in insect cells. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RNaseL,uniProtId:Q05823-1,ncbiNodeId:9606,antigenRange:1-741,antigenLength:741,antigenImageFileName:MA1-16575_RNaseL_Q05823-1_House_mouse.svg,antigenImageFileNamePDP:MA1-16575_RNaseL_Q05823-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_568708

Product Specific Information

This antibody does not react with mouse or rat samples.

Target Information

A virally induced endoribonuclease, RNase L is the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L functions in counteracting prostate cancer, via apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.