Thermo Fisher Scientific XRCC3 Monoclonal Antibody (10F1/6)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:500

-

Immunocytochemistry (ICC/IF)

1:10-1:500

-

Product Specifications

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

10F1/6

Immunogen

His-tagged human XRCC3, over-expressed in E. coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

4° C, do not freeze

Shipping conditions

Wet ice

RRID

AB_568779

Product Specific Information

This antibody does not react with mouse samples.

The target sequence has 100% sequence homology with non-human primate and 93% sequence homology with sheep, rat, and bovine.

Suggested positive control: antigen standard for XRCC3 (transient overexpression lysate).

Target Information

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.