Thermo Fisher Scientific NPC1 Polyclonal Antibody
Human 및 Mouse에서 반응하는 Rabbit Polyclonal NPC1 항체. Western blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태. 인간 신장 조직 lysate를 양성 대조군으로 권장. 연구용 전용 제품.
- 카탈로그번호
- PA520753
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the carboxy terminus of human NPC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156374 |
Product Specific Information
- A suggested positive control is human kidney tissue lysate.
- PA5-20753 can be used with blocking peptide PEP-0867.
Target Information
Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by abnormal sequestration of lipids including cholesterol and glycosphingolipids.
The NPC1 protein resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain.
NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolyzed and released as free cholesterol.
Additionally, NPC1 has been identified as a risk locus for early-onset and morbid adult obesity in European populations.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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