Thermo Fisher Scientific LDLR Polyclonal Antibody
LDLR 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot과 IHC에 적합하며, 인간·마우스·랫트 시료에 반응. 항원 친화 크로마토그래피로 정제된 액상 항체로, 2–8°C 보관 가능. 연구용 전용 시약.
- 카탈로그번호
- PA520752
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Chicken / IgY |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide near the center of human LDL-R |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152335 |
Product Specific Information
- Suggested positive control: human liver tissue lysate
- PA5-20752 can be used with blocking peptide PEP-0866
Target Information
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL normally binds at the cell membrane and is internalized into lysosomes, where the protein is degraded and cholesterol becomes available for repression of HMG CoA reductase, the rate-limiting enzyme in cholesterol synthesis. Concurrently, cholesterol ester synthesis is stimulated.
Mutations in the LDL-R gene cause familial hypercholesterolemia, an autosomal dominant disorder. LDL-R, along with SCARB1, CLDN1, and CD81, is also implicated as an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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