Thermo Fisher Scientific PGC1 alpha Polyclonal Antibody

Product Specifications

Product Specific Information

Immunogen sequence:
FGHPSQAVFDD EADKTGELRD SDFSNEQFSK LPMFINSGLA MDGLFDDSED ESDKLSYPWD GTQSYSLFNV SPSCSSFNSP CRDSVSRPKS L

Highest antigen sequence identity to the following orthologs:

• Mouse: 90%
• Rat: 90%

Target Information

PGC1 alpha is a transcriptional coactivator that regulates genes involved in energy metabolism. It interacts with PPARγ, enabling interactions with multiple transcription factors. PGC-1 alpha can regulate the activities of cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and mitochondrial biogenesis, playing a major role in muscle fiber type determination. It may also be involved in controlling blood pressure, regulating cellular cholesterol homeostasis, and the development of obesity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.