Thermo Fisher Scientific PGC1 alpha Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human PGC1 alpha

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2665049

Product Specific Information

Immunogen sequence: FGHPSQAVFDD EADKTGELRD SDFSNEQFSK LPMFINSGLA MDGLFDDSED ESDKLSYPWD GTQSYSLFNV SPSCSSFNSP CRDSVSRPKS L

Highest antigen sequence identity to the following orthologs - mouse 90%, rat 90%.

Target Information

PGC1 alpha is a transcriptional coactivator that regulates the genes involved in energy metabolism. It interacts with PPARgamma, which permits it`s interaction with multiple transcription factors. PGC-1 Alpha can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. It may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.