Thermo Fisher Scientific Human LAMP2 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the center of human LAMP-2.
PEP-0312 can be used as a blocking peptide with polyclonal antibody PA5-20177.

Target Information

LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands and may play a role in tumor cell metastasis, as well as in lysosomal protection, maintenance, and adhesion.
Prior to posttranslational modification, LAMP2 is approximately 46 kDa polypeptide. Mature, functional LAMP2 is extensively glycosylated with various N-linked and O-linked oligosaccharides, resulting in a total molecular weight of about 100–130 kDa.
LAMP2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. It is used to monitor a very selective form of autophagy called chaperone-mediated autophagy.
The LAMP protein has three variant forms: LAMP-2A, LAMP-2B, and LAMP-2C. LAMP2, together with CD107a/LAMP-1, is a major constituent of lysosomal membrane and is essential for lysosome biogenesis and fusion with phagosomes. LAMP2 deficiency causes accumulation of autophagosomes in many tissues, leading to cardiomyopathy and myopathy (Danon’s disease).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.