
Thermo Fisher Scientific Phospho-CtIP (Thr847) Polyclonal Antibody
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Applications
Tested Dilution
Publications
Western Blot (WB)
1:1,000
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr847 conjugated to KLH if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
CtIP,
uniProtId:
Q99708-1,
ncbiNodeId:
9606,
antigenRange:
847,
antigenLength:
897,
antigenImageFileName:
PA5-95666_CtIP_Q99708-1_Rabbit.svg,
antigenImageFileNamePDP:
PA5-95666_CtIP_Q99708-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
~0.15 mg/mL
Purification
Antigen Affinity Chromatography
Storage buffer
10mM HEPES, pH 7.5, with 100µg/mL BSA, 50% glycerol, 0.15M NaCl
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807468
Product Specific Information
Antigen Affinity Purified from Pooled Serum
Target Information
CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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