Thermo Fisher Scientific JMJD2C Monoclonal Antibody (OTI4B1)
JMJD2C(KDM4C) 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체. IHC, ICC/IF, Flow Cytometry에 사용 가능. 인간 시료 반응성, Mouse IgG1 아이소타입. 액상 형태로 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B1 |
| Immunogen | Full length human recombinant protein of KDM4C produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723298 |
Target Information
Jumonji domain-containing protein 2C (JMJD2C), also known as Lysine-specific demethylase 4C (KDM4C), is a histone demethylase that specifically demethylates Lys-9 and Lys-36 residues of histone H3, thereby playing a central role in the histone code.
KDM4C does not demethylate histone H3 Lys-4, H3 Lys-27, or H4 Lys-20. It demethylates trimethylated H3 Lys-9 and H3 Lys-36 residues, with no activity on mono- or dimethylated residues.
Demethylation of Lys residues generates formaldehyde and succinate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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