Thermo Fisher Scientific SATB1 Monoclonal Antibody (OTI3E12)
SATB1 단백질을 인식하는 마우스 단클론 항체로, WB, IHC, ICC, ChIP 등 다양한 응용에 사용 가능. 인간, 생쥐, 랫드 반응성. 액상 형태로 1 mg/mL 농도, PBS 버퍼에 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
| ChIP assay (ChIP) | 2.5 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3E12 |
| Immunogen | Full length human recombinant protein of SATB1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725296 |
Target Information
SATB1 (DNA-binding protein SATB1) is a crucial silencing factor involved in the initiation of X inactivation mediated by Xist RNA during embryogenesis and in lymphoma. It binds to DNA at AT-rich sequences and nuclear matrix- or scaffold-associated regions, recognizing the sugar-phosphate structure of double-stranded DNA. SATB1 functions as a transcriptional repressor regulating nuclear and viral gene expression in a phosphorylation- and acetylation-dependent manner by binding to matrix attachment regions and inducing local chromatin-loop remodeling. It is essential for the maturation of immune T-cell CD8SP from thymocytes. SATB1-binding sites also provide a chromatin context preferentially targeted by HIV-1 integration machinery, and HIV-1 Tat may overcome SATB1-mediated repression of IL1 and IL2RA in T-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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