Thermo Fisher Scientific Phospho-IRF7 (Ser477) Polyclonal Antibody
IRF7 단백질의 Ser477 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며, 인간, 마우스, 랫트 시료에 반응. 고순도 정제 및 안정적 PBS/glycerol 저장 포뮬러 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (IHC) | 1:50–1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IRF7 (Accession Q92985), corresponding to amino acid residues around phosphorylated Ser477 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817582 |
Product Specific Information
Antibody detects endogenous levels of IRF7 only when phosphorylated at Ser477.
Target Information
Interferons (IFNs) are involved in numerous immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms.
During infection, host-virus interactions signal downstream molecules such as transcription factors like IFN regulatory factor-3 (IRF3), which stimulate transcription of IFN-α/β genes.
IRF7 is involved in transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. It plays a key role in the innate immune pathway, interacting with Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM, functioning as an intermediate in TLR4 and TLR9 signaling.
There are at least four differentially spliced isoforms of IRF7, although their functions have not been clearly established.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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