Thermo Fisher Scientific Phospho-IRF7 (Ser477) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of IRF7 only when phosphorylated at Ser477.

Target Information

Interferons (IFNs) are involved in numerous immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms.
During infection, host-virus interactions signal downstream molecules such as transcription factors like IFN regulatory factor-3 (IRF3), which stimulate transcription of IFN-α/β genes.
IRF7 is involved in transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. It plays a key role in the innate immune pathway, interacting with Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM, functioning as an intermediate in TLR4 and TLR9 signaling.
There are at least four differentially spliced isoforms of IRF7, although their functions have not been clearly established.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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