Thermo Fisher Scientific SEMA4D Polyclonal Antibody
Rabbit polyclonal antibody targeting Human SEMA4D (CD100), validated for WB and IP applications. Unconjugated liquid form at 1 mg/mL concentration. Predicted cross-reactivity with Mouse. Suitable for research use in neuronal and immune signaling studies.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 812–862 of Human Sema Somain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM), and Short Cytoplasmic Domain (Semaphorin) 4D |
| Target Family | CD100 (SEMA4D) |
| UniProt ID | Q92854-1 |
| Species | Human |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
Semaphorins are neuronal chemorepellants that guide pioneering neurons during nervous system development.
CD100 (also known as semaphorin 4D), a 150 kDa homodimer, induces B cell aggregation and enhances viability in vitro.
It modulates CD40-CD40L signaling by promoting B cell survival and downregulating CD23 expression.
CD72 serves as a receptor for CD100, regulating B cell signaling.
CD100 is expressed on resting and PHA-stimulated T cells, weakly on NK cells, EBV-transformed B cells, monocytes, and tumor/peripheral blood T cell lines, and more strongly on activated T and B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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