Thermo Fisher Scientific CD7 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.

Target Information

CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily.
The N-terminal amino acids (1–107) are highly homologous to Ig kappa-L chains, whereas the C-terminal region of the extracellular domain is proline-rich, forming a stalk from which the Ig domain projects.

CD7 is expressed on most immature and mature T-lymphocytes and T cell leukemia cells. It is also found on natural killer cells, a small subpopulation of normal B cells, and malignant B cells. Cross-linking surface CD7 modulates T cell and NK cell activity, affecting calcium fluxes, adhesion molecule expression, cytokine secretion, and proliferation. CD7 associates directly with phosphoinositol 3′-kinase, and its ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.

Expression of CD7 is an important marker used in leukemia diagnostics.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.