Thermo Fisher Scientific CD7 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CD7 protein. Suitable for WB, IHC, and IP applications. Recommended for research use only. Offers high specificity and stability with 1 mg/mL liquid form. Store at 4°C and ship on wet ice.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 190 to 240 of human CD7 molecule |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily.
The N-terminal amino acids (1–107) are highly homologous to Ig kappa-L chains, whereas the C-terminal region of the extracellular domain is proline-rich, forming a stalk from which the Ig domain projects.
CD7 is expressed on most immature and mature T-lymphocytes and T cell leukemia cells. It is also found on natural killer cells, a small subpopulation of normal B cells, and malignant B cells. Cross-linking surface CD7 modulates T cell and NK cell activity, affecting calcium fluxes, adhesion molecule expression, cytokine secretion, and proliferation. CD7 associates directly with phosphoinositol 3′-kinase, and its ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.
Expression of CD7 is an important marker used in leukemia diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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