Thermo Fisher Scientific SEMA4D Polyclonal Antibody
Human SEMA4D(CD100) 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제되었으며 액상 형태로 제공. 4°C 보관, 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 812 to 862 of Human Sema Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain (Semaphorin) 4D (CD100, UniProt ID: Q92854-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
Semaphorins are neuronal chemorepellants that guide pioneering neurons during nervous system development.
CD100 (also known as Semaphorin 4D) is a 150 kDa homodimer that induces B cell aggregation and enhances viability in vitro.
It modulates CD40–CD40L signaling by promoting B cell aggregation and survival, while downregulating CD23 expression.
CD72 acts as a lymphocyte receptor for CD100, regulating B cell signaling.
CD100 is expressed on resting and PHA-stimulated T cells, weakly on NK cells, EBV-transformed B cells, monocytes, and tumor/peripheral blood T cell lines, with higher density on activated T and B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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