Thermo Fisher Scientific Phospho-Merlin (Ser518) Polyclonal Antibody
Phospho-Merlin (Ser518) 특이적 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에서 WB, IHC, ICC, ELISA 등에 사용 가능. 고순도 Protein A 정제 및 안정적 액상 형태로 제공되며, NF2 관련 신경섬유종증 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human Merlin around the phosphorylation site of Ser518 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NF2 encodes a protein, Merlin, that is similar to some members of the ERM family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. Merlin interacts with cell-surface proteins, cytoskeletal regulators, and ion transport proteins. NF2 is highly expressed during embryonic development and in adults within Schwann cells, meningeal cells, lens, and nerve tissues. Mutations in NF2 are associated with neurofibromatosis type II, characterized by nervous system and skin tumors as well as ocular abnormalities. Two predominant isoforms and several minor isoforms are produced by alternatively spliced transcripts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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