Thermo Fisher Scientific IQGAP3 Polyclonal Antibody

Thermo Fisher Scientific IQGAP3 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:200–1:1,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total IQGAP3 protein.

Target Information

IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac1, linking their activation to the cytoskeleton during neuronal morphogenesis.
A novel member of the IQGAP family, IQGAP3 is highly expressed in brain, localizing to axons of hippocampal neurons.
It contains one Ras-GAP domain, a CH (calponin-homology) domain, and four IQ domains.
The gene encoding IQGAP3 is located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes, and comprises nearly 8% of the human genome.
Chromosome 1 includes many disease-associated genes related to familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia, and Usher syndrome.
Aberrations in chromosome 1 are found in various cancers, including head and neck cancer, malignant melanoma, and multiple myeloma.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.